After the last software update of my librem 15 v3, my usb mouse loses control of the cursor after a few seconds of inactivity, and I have to click any button to reactive control. The trackpad continues to control the cursor without any intervention required.
Another user on the purism forums suggested that connecting USB devices after disk decryption would mitigate this issue (https://forums.puri.sm/t/usb-mouse-suspension/3742).