neutralized ME for skylake with MFS partition left intact (https://github.com/kakaroto/me_cleaner/tree/me11) needs to be tested to see if it causes any side effects. Only side effect I saw (poweroff/reboot issues) seem to be limited to the prototype I have, it could be because of the SSD model in it, or the PureOS version (alpha1 I think?) or kernel or maybe it's a difference in prototype vs retail machine or something else that's causing this issue. The retail Librem 13 v1 I have (with an SSD using latest PureOS build) doesn't seem affected by any side effects that I can see..
more tests are required before we can see "neutralized ME works and it's fine".